I have a family history of high triglyceride levels. My readings were extremely elevated. I was put on Tricor and immediately got better results. It also decreased my cholesterol levels, which were borderline to sightly elevated. Each year I got better and lower readings for triglycerides. However, after about six years, I experienced frequent disgestive problems (diarrhea, stomach discomfort) which were not listed as possible side effects of Tricor. Various medical tests and treatments failed to relieve the problem. Convinced that the medicine was affecting my digestive functions, I asked my doctor to allow me to go off the Tricor to see if that would make a difference. After about two weeks off the Tricor, my digestive system dramatically improved and has remained in good working order. My conclusion? Long term use of this medicine began to interfere with diegestive function.